AustralieFrV1, Main, Exploration, bibRecord, 00D888

Physical and Genetic Mapping of the Dipeptidase Gene DPEP1 to 16q24.3

Identifieur interne : 00D888 ( Main/Exploration ); précédent : 00D887; suivant : 00D889

Physical and Genetic Mapping of the Dipeptidase Gene DPEP1 to 16q24.3

Auteurs : Estelle Austruy [France] ; Cécile Jeanpierre [France] ; Corinne Antignac [France] ; Scott A. Whitmore [France] ; Nguyen Van Cong [France] ; Alain Bernheim [France] ; David F. Callen [France] ; Claudine Junien [France]

Source :

Genomics [ 0888-7543 ] ; 1993.

RBID : ISTEX:0CDB208CC2A3F610D4D93129EB7CBCFF65DC3A28

Abstract

Abstract: We report the subregional physical and genetic mapping on chromosome 16q of a cDNA clone selected as a potential tumor/growth suppressor sequence. By DNA sequencing and RNA expression pattern, this clone was identified as part of the renal dipeptidase gene (DPEP1). Using somatic cell hybrids carrying either different human chromosomes or chromosome 16 segments, we confirm and refine the physical mapping of DPEP1 to the chromosome 16 subregion q24.3. Two RFLPs, a biallelic polymorphism detected by TaqI and a VNTR detected by BamIII, Eco RI, and BgIII, are described. Using the VNTR polymorphism, DPEP1 was shown to be linked to D16S7 with a maximum lod score of 5.8 at a recombination fraction of 0.03.

Url:

https://api.istex.fr/document/0CDB208CC2A3F610D4D93129EB7CBCFF65DC3A28/fulltext/pdf

DOI: 10.1006/geno.1993.1126

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: We report the subregional physical and genetic mapping on chromosome 16q of a cDNA clone selected as a potential tumor/growth suppressor sequence. By DNA sequencing and RNA expression pattern, this clone was identified as part of the renal dipeptidase gene (DPEP1). Using somatic cell hybrids carrying either different human chromosomes or chromosome 16 segments, we confirm and refine the physical mapping of DPEP1 to the chromosome 16 subregion q24.3. Two RFLPs, a biallelic polymorphism detected by TaqI and a VNTR detected by BamIII, Eco RI, and BgIII, are described. Using the VNTR polymorphism, DPEP1 was shown to be linked to D16S7 with a maximum lod score of 5.8 at a recombination fraction of 0.03.</div>
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Physical and Genetic Mapping of the Dipeptidase Gene DPEP1 to 16q24.3

Physical and Genetic Mapping of the Dipeptidase Gene DPEP1 to 16q24.3

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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